Acivir by Cipla (Acyclovir)

$ 129.54$ 630.14

Category: Anti-Viral
Commercial name: Acivir by Cipla
Active ingredient: Acyclovir
Production form: Pills
Available dosage: 200 mg, 400 mg, 800 mg

SKU: N/A Category: Tags: , , ,


Acivir by Cipla (Acyclovir). Dosage, Side Effects, Interactions

Acivir by Cipla (Acyclovir) is one of the nucleoside analogues. It is used for the therapy and prophylaxis of herpes simplex and varicella zoster infections.

Acivir by Cipla (Acyclovir) is used to treat or prevent infections with the following viruses:

  • Herpes simplex virus types 1 and 2
  • Varicella zoster virus.

These pathogens cause genital herpes, labial herpes, herpes simplex encephalitis , herpes simplex keratitis, herpes zoster , ophthalmic zoster, and chickenpox .

Depending on the indication, aciclovir is available in various dosage forms: as lip cream, cream, film-coated tablet, infusion, injection, eye ointment or suspension. As an infusion, aciclovir is mainly used when a severe course of the disease is to be expected due to a weakened immune system. Newborns and infants can also be treated with aciclovir.


How Acivir by Cipla (Acyclovir) works

Only when it has reached the infected cells is aciclovir metabolized to the active ingredient aciclovir triphosphate. This inhibits the polymerase enzyme in the virus so that it can no longer synthesize DNA. The enzyme erroneously incorporates the active substance into the new virus DNA, which leads to the chain being broken. This stops the virus from multiplying.



Because the bioavailability – of tablets with aciclovir – is only 10 to 30% and the half-life is also relatively short at just under three hours, drugs with the active ingredient must be administered frequently (see dosage). When the highest plasma concentrations are reached depends on the dosage form and the dose – injections work faster than, for example, an ointment. 75 to 80% of the drug is excreted unchanged in the kidneys.


Dosage of Acivir by Cipla (Acyclovir)

It is important that aciclovir treatment is started as early as possible. The active ingredient must be administered comparatively frequently for the therapy to be successful. In principle, sufficient fluid intake should be ensured during treatment; this is especially true for older patients. Depending on the dosage form, different dosages are recommended.


Aciclovir cream against herpes labialis is applied thinly to the infected areas of skin five times a day every four hours.


In the case of a herpes simplex infection, adults should take one tablet containing 200 mg aciclovir five times a day – an interval of four hours is recommended. For herpes zoster, a dose of 800 mg every four hours is considered effective.

infusion solution

An infusion solution of, for example, 25 mg/ml concentrate should be administered by slow intravenous infusion over one hour every eight hours. Depending on the indication, the treatment should last from 5 to 21 days. Dosing for the treatment of children should be calculated based on body weight (e.g. 20 mg/kg body weight every 4 hours). If the kidney function is impaired, caution is required, especially with infusions.

Dosage in specific patient groups

In special patient groups, the dosage of aciclovir may need to be adjusted depending on the dosage form:

  • In elderly patients, the possibility of impaired renal function must be considered. Sufficient fluid intake during therapy is particularly important here.
  • In children with renal impairment, the dose should be adjusted to the degree of impairment.
  • In obese patients, the dose for an infusion should not only be calculated according to body weight – otherwise there is a risk of very high plasma concentrations.


Experience with aciclovir overdose is limited. However, increased side effects are to be expected. In the event of an overdose, staying hydrated is particularly important to reduce the likelihood of crystals forming in the urine. If necessary, the active ingredient must be removed from the bloodstream by hemodialysis.


Side effects of Acivir by Cipla (Acyclovir)

The most common side effects of aciclovir therapy include headaches, dizziness and indigestion, and skin reactions can also occur. The following side effects can occur during therapy – depending on the dosage form, possibly with different frequencies:


  • dizziness
  • headache
  • nausea
  • Vomit
  • Diarrhea
  • abdominal pain
  • itching
  • skin rash
  • pruritus
  • Phlebitis.


  • urticaria
  • diffuse hair loss
  • fatigue
  • Fever
  • Burning or stinging on the treated skin areas
  • desquamation of the skin
  • anemia
  • thrombocytopenia
  • leukopenia.


  • anaphylactic reactions
  • dyspnea
  • transient increases in bilirubin and liver enzymes
  • angioedema
  • Increase in serum urea and creatinine
  • erythema
  • contact dermatitis.

Very rare:

  • anemia
  • leukopenia
  • thrombocytopenia
  • neutropenia
  • dyspnea
  • diarrhea
  • stomach pain
  • physical restlessness
  • confusional states
  • tremor
  • ataxia
  • dysarthria
  • hallucinations
  • symptoms of psychosis
  • seizures
  • headache
  • dizziness
  • sleepiness
  • fatigue
  • Fever
  • local inflammatory reactions
  • anaphylaxis
  • encephalopathy
  • disturbances of consciousness up to coma
  • hepatitis
  • jaundice
  • renal dysfunction
  • acute renal failure
  • kidney pain
  • angioedema.


If aciclovir is used as a cream, no interactions with other medicinal products are to be expected. If the active ingredient is used as an infusion solution or tablet, interactions with the following active ingredients may occur:

  • probenecid
  • cimetidine
  • theophylline
  • mycophenolate mofetil
  • lithium
  • ciclosporin
  • Tacrolimus .


Drugs with aciclovir must not be taken if you are hypersensitive to the active ingredient or components of the drug to be administered.



There is no evidence that aciclovir impairs fertility. It should only be used during pregnancy if the expected benefit outweighs the risk.



The active substance from aciclovir cream passes into breast milk, although the dose measured therein was negligible. Caution should be exercised when breastfeeding after an aciclovir infusion. If the therapy is in the form of tablets, you should not breastfeed during this time.


Driving ability

There are no studies examining the ability to drive or operate machines under aciclovir therapy. So far, no effects of the active substance on it have become known.

Further details on this active ingredient can be found in the relevant product information.

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Additional information


200 mg, 400 mg, 800 mg


30, 60, 90, 120, 180


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