$ 117.76$ 306.17

Category: Other
Commercial name: Aricept
Active ingredient: Donepezil
Production form: Pills
Available dosage: 5 mg, 10 mg

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Aricept (Donepezil). Dosage, Side Effects, Interactions

ARICEPT contains the active substance donepezil hydrochloride. ARICEPT (donepezil hydrochloride) belongs to a group of medicines called acetylcholinesterase inhibitors. Donepezil increases levels of a substance (acetylcholine) in the brain involved in memory function by slowing down the breakdown of acetylcholine.

ARICEPT is intended for the symptomatic treatment of patients with mild to moderate Alzheimer’s dementia. Symptoms include increasing memory loss, confusion, and behavior changes. As a result, patients suffering from Alzheimer’s dementia find it increasingly difficult to carry out normal daily tasks.

ARICEPT is for adult use only.

What you need to know before you take ARICEPT

ARICEPT must not be taken

  • if you are allergic to donepezil hydrochloride, related substances (piperidine derivatives) or any of the other ingredients of the medicine (listed in section 6).

Warnings and Precautions

If these warnings apply to you or have applied to you in the past, talk to your doctor or pharmacist before taking ARICEPT.

  • Stomach or intestinal ulcer

  • Seizures

  • A heart condition (such as an irregular or very slow heartbeat, heart failure, heart attack)

  • A heart condition called “prolonged QT interval” or a history of certain abnormal heart rhythms called torsades de pointes, or if someone in your family has “prolonged QT interval”.

  • Low levels of magnesium or potassium in the blood

  • Asthma or other chronic lung diseases

  • Liver dysfunction or hepatitis

  • Bladder emptying disorders or mild renal dysfunction

Please also inform your doctor if you are pregnant or think you may be pregnant.

Children and young people

ARICEPT is not recommended for use in children and adolescents under 18 years of age.

Taking ARICEPT with other medicines

Tell your doctor or pharmacist if you are taking/using, have recently taken/used or might take/use any other medicines. This also includes medicines that do not require a prescription. The same applies to medicines that you may take in the future in addition to ARICEPT. This is important because other medicines can decrease or increase the effect of ARICEPT.

In particular, tell your doctor if you are taking the following types of medicines:

  • Medicines used to treat heart rhythm problems, e.g. amiodarone, sotalol

  • medicines for depression, e.g. B citalopram, escitalopram, amitriptyline, fluoxetine

  • Medicines for psychosis, e.g. B pimozide, sertindole, ziprasidone

  • Medicines for bacterial infections, e.g. clarithromycin, erythromycin, levofloxacin, moxifloxacin, rifampicin

  • Medicines for fungal infections, e.g. Ketoconazole

  • other medicines used to treat Alzheimer’s dementia e.g. galantamine

  • Painkillers or medicines to treat arthritis, e.g. acetylsalicylic acid, non-steroidal anti-inflammatory drugs such as ibuprofen or diclofenac

  • Anticholinergics, e.g. tolterodine

  • Anticonvulsants, e.g. phenytoin, carbamazepine

  • Medicines used to treat heart disease, e.g. quinidine, beta-blockers (propanolol and atenolol)

  • Muscle relaxants, e.g. diazepam, succinylcholine

  • general anesthetics

  • Non-prescription medicines, e.g. herbal medicines

If you are about to have an operation that will require general anesthesia, tell your doctor and the anesthetist that you are taking ARICEPT. This is important as your medication may affect the amount of anesthetic needed.

Patients with kidney disease and mild to moderate liver disease can take ARICEPT, but should tell their doctor first. Patients with severe liver disease should not take ARICEPT.

Tell your doctor or pharmacist the name of your guardian. Your caregiver will help you take your medicines as directed.

Taking ARICEPT with food, drink and alcohol

Food intake does not affect the effect of ARICEPT.

ARICEPT should not be taken with alcohol as this can affect its effectiveness.

Pregnancy, lactation and fertility

If you are pregnant or breast-feeding, think you may be pregnant or planning to become pregnant, ask your doctor or pharmacist for advice before taking any medicine.

ARICEPT should not be taken while breastfeeding.

Ability to drive and use machines

Alzheimer’s dementia can affect your ability to drive and use machines, and you must not engage in these activities unless your doctor tells you otherwise.

In addition, your medicine may cause tiredness, dizziness and muscle cramps. If you notice any of these effects, you must not drive or use machines.

ARICEPT contains lactose. Therefore , please only take ARICEPT after consulting your doctor if you know that you suffer from an intolerance to certain sugars.

3. How to take ARICEPT?

Dosage for Aricept (Donepezil)?

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. The initial recommended dose at the beginning of treatment is 5 mg (one white tablet) each night before bedtime. After a month your doctor may increase the dose to 10 mg (one yellow tablet) every night before bed.

The dose of your medicines may change based on how long you take them and on your doctor’s recommendation. The maximum recommended dose per day is 10 mg donepezil hydrochloride.

Always take Aricept exactly as your doctor or pharmacist has told you.

Do not change the dosage without medical advice.

How to take ARICEPT

Take your ARICEPT tablet with water before bed.

Children and young people

ARICEPT is not recommended for use in children and adolescents under 18 years of age.

If you take more ARICEPT than you should

If you take more ARICEPT than you should, talk to a doctor straight away or go to your nearest hospital casualty department. Take the medicine pack and any remaining tablets with you.

Symptoms of an overdose may include: nausea, vomiting, increased salivation, sweating, low heart rate, low blood pressure (lightheaded or dizzy when standing), breathing problems, loss of consciousness and seizures.

If you forget to take ARICEPT

If you forget to take your medicine, take the next tablet as recommended. If you forget to take your tablets for more than a week, please contact your doctor before taking any more tablets.

If you stop taking ARICEPT

Treatment with ARICEPT should never be stopped without medical advice.

After discontinuation of treatment, a slow wear off of the beneficial effect of ARICEPT is observed.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

How long should you take ARICEPT?

The duration of treatment is determined individually by your doctor or pharmacist. You will be followed up by your doctor at regular intervals to review your treatment and your symptoms.

Side effects of Aricept (Donepezil)

Like all medicines, ARICEPT can cause side effects, although not everyone gets them.

The following side effects have occurred in patients treated with ARICEPT. Tell your doctor if you get any of these side effects while taking ARICEPT.

Serious side effects:
Tell your doctor straight away if you notice these serious side effects. You may need urgent medical treatment.

  • Hepatic dysfunction eg hepatitis. The symptoms of hepatitis are nausea, vomiting, loss of appetite, feeling unwell, fever, itching, yellowing of the skin and eyes, and dark-colored urine (may affect up to 1 in 1,000 people)

  • Stomach or intestinal ulcers. The symptoms of an ulcer are pain and discomfort between the navel and the breastbone (may affect up to 1 in 100 people)

  • Stomach or intestinal bleeding. This can cause black, tar-like stools and visible blood from the rectum (may affect up to 1 in 100 people)

  • seizures (may affect up to 1 in 100 people)

  • fever with muscle stiffness, sweating or changes in consciousness (a so-called neuroleptic malignant syndrome which may affect up to 1 in 10,000 people)

  • Muscle weakness, tenderness and pain, especially if you are feeling unwell, have a high temperature or dark colored urine at the same time. These symptoms could be caused by an abnormal breakdown of muscle tissue that can be life-threatening and lead to kidney problems (called rhabdomyolysis, which may affect up to 1 in 10,000 people)

Other side effects

Very common side effects (may affect more than 1 in 10 people):

  • Diarrhea

  • headache

Common side effects (may affect up to 1 in 10 people):

  • Muscle cramp

  • fatigue

  • insomnia

  • a cold

  • hallucinations (seeing or hearing things that are not really there)

  • Unusual dreams (including nightmares)

  • states of arousal

  • aggressive behavior

  • fainting

  • dizziness

  • Gastrointestinal complaints

  • rash

  • urinary incontinence

  • pain

  • Accident (patients are more prone to falling or injuring themselves)

Uncommon side effects (may affect up to 1 in 100 people):

  • slowing of the heartbeat

  • Increased saliva production

Rare side effects (may affect up to 1 in 1,000 people):

  • Stiffness, tremors or uncontrollable movements, especially in the face and tongue, but also in the limbs

Side effects with frequency not known (cannot be estimated from the available data):

  • Changes in heart activity that can be seen on an electrocardiogram (ECG) as ‘prolonged QT interval’

  • Fast, irregular heartbeat, fainting, which can be symptoms of a life-threatening condition known as torsades de pointes

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Additional information


5 mg, 10 mg


30, 60, 90, 120, 180


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