Buspar (Buspirone)

$ 111.94$ 192.44

Category: Anti-Anxiety
Commercial name: Buspar
Active ingredient: Buspirone
Production form: Pills
Available dosage: 5mg, 10mg

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Description

Buspar (Buspirone). Dosage, Side Effects, Interactions

Buspar (Buspirone) is a prescription drug used to treat the symptoms of anxiety disorders. Buspar can be used alone or with other medicines.

Buspar (Buspirone) belongs to a class of medicines called Antianxiety Agents, Anxiolytics, Nonbenzodiazepines.

What are the possible side effects of Buspar?

Buspar can cause serious side effects, including:

  • chest pain,
  • shortness of breath and
  • drowsiness

Get medical help right away if you have any of the symptoms listed above.

The most common side effects of Buspar are:

  • Headache,
  • Dizziness,
  • Sleepiness,
  • sleep problem (insomnia),
  • Nausea,
  • upset stomach and
  • feeling nervous or excited
 
Tell the doctor if you have any side effects that bother you or that don’t go away.

These are not all possible side effects of Buspar. For more information, contact your doctor or pharmacist.

DESCRIPTION OF Buspar (Buspirone)

Buspirone Hydrochloride Tablets, USP, is an anti-anxiety drug that is chemically or pharmacologically unrelated to the benzodiazepines. Barbiturates or other sedatives/anxiolytics.

Buspirone Hydrochloride, USP is a white crystalline powder. It is very water soluble; freely soluble in methanol and in methylene chloride; sparingly soluble in ethanol and in acetonitrile; very slightly soluble in ethyl acetate and practically insoluble in hexanes. Its molecular weight is 422. Chemically, buspirone hydrochloride is 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione monohydrochloride. The molecular formula C twenty-one H 31 N 5 OR two & bull; HCl is represented by the following structural formula:

 

Each buspirone hydrochloride tablet intended for oral administration contains 5 mg or 10 mg or 15 mg or 30 mg buspirone hydrochloride (equivalent to 4.6 mg, 9.1 mg, 13.7 mg and 27.4 mg buspirone free base respectively). In addition, each tablet contains the following inactive ingredients: colloidal silicon dioxide, lactose monohydrate, magnesium stearate, microcrystalline cellulose and sodium starch glycolate. The 5mg and 10mg tablets are graded to allow them to be divided in half. Thus, the 5 mg tablet can also provide a 2.5 mg dose and the 10 mg tablet can provide a 5 mg dose. The 15mg and 30mg tablets are graded to either be divided in half or divided into three. Thus, a single 15 mg tablet can provide the following doses: 15 mg (whole tablet), 10 mg (two thirds of a tablet), 7.5 mg (one half of a tablet) or 5 mg (one third of a tablet) . A single 30 mg tablet can deliver the following doses: 30 mg (entire tablet), 20 mg (two thirds of a tablet), 15 mg (one half of a tablet), or 10 mg (one third of a tablet).

 

INDICATIONS

Buspirone hydrochloride tablets are indicated for the treatment of anxiety disorders or for the short-term relief of anxiety symptoms. Anxiety or tension related to everyday stress does not usually require treatment with an anxiolytic.

The effectiveness of buspirone hydrochloride tablets has been demonstrated in controlled clinical trials in outpatients with a diagnosis consistent with Generalized Anxiety Disorder (GAD). Many of the patients included in these studies also had concomitant depressive symptoms, and buspirone hydrochloride tablets reduced anxiety in the presence of these coexisting depressive symptoms. Patients studied in these studies had had symptoms for a period ranging from 1 month to over 1 year prior to the study, with a mean duration of symptoms of 6 months. Generalized Anxiety Disorder (300.02) is described in the American Psychiatric Association’s Diagnostic and Statistical Manual III1 as follows:

Generalized persistent anxiety (lasting at least 1 month) manifesting as symptoms from three of the following four categories:

motor voltage

Feeling shaky, nervous, jittery, tremors, tightness, muscle pain, feeling tired, inability to relax, twitching of eyelids, frowning, facial tension, fidgeting, restlessness, startled easily.

autonomic hyperactivity

Sweating, palpitations or racing heart, cold, clammy hands, dry mouth, dizziness, lightheadedness, paraesthesia (tingling in hands or feet), upset stomach, hot or cold spells, frequent urination, diarrhea, pit of stomach discomfort, lump in the throat, flushing , pallor, high resting heart rate and breathing rate.

Worrying Expectation

 
 

Fear, worry, anxiety, rumination and anticipation of misfortune for oneself or others.

vigilance and scanning

Hyperattention leading to distractibility, difficulty concentrating, insomnia, feeling peripheral, irritability, and impatience.

The effectiveness of buspirone hydrochloride tablets with long-term use, that is, longer than 3 to 4 weeks, has not been proven in controlled studies. There is no evidence that systematically governs the appropriate duration of treatment for GAD. However, in a long-term use study, 264 patients were treated with buspirone hydrochloride tablets for 1 year with no adverse effects. Therefore, the doctor who decides to use buspirone hydrochloride tablets for a long period of time should periodically review the usefulness of the drug for the individual patient.

 

DOSAGE AND APPLICATION OF Buspar (Buspirone)

The recommended starting dose is 15 mg daily (7.5 mg bid). To achieve optimal therapeutic response, the dosage may be increased by 5 mg per day at 2 to 3 day intervals as needed. The maximum daily dose should not exceed 60 mg per day. In clinical trials that allow for dose titration, divided doses of 20 mg to 30 mg per day have typically been used.

The bioavailability of buspirone is increased when ingested compared to the fasted state. Consequently, patients should be consistent in taking buspirone in terms of timing of dosing. either always with or always without food.

If buspirone is to be administered with a strong CYP3A4 inhibitor, the dosing recommendations in the section should be followed.

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Additional information

Dosage

5 mg, 10 mg

Quantity

30, 60, 90, 120, 180

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