Celebrex

$ 99.81$ 191.78

Category: Pain Management
Commercial name: Celebrex
Active ingredient: Celecoxib
Production form: Pills
Available dosage: 100 mg, 200 mg

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Description

Celebrex (Celecoxib). Dosage, Side Effects, Interactions

Celecoxib is primarily used for degenerative joint problems as a result of arthrosis or rheumatoid arthritis and for Bechterew’s disease .

Application type

Celebrex can be taken with or without food.

Depending on the manufacturer, the contents of one celecoxib capsule can be added to applesauce, rice gruel, yogurt, or mashed banana for patients who have difficulty swallowing.

 

How Celebrex (Celecoxib)

Coxibs such as celecoxib fight inflammatory processes and the associated pain by inhibiting or interrupting the formation of cyclooxygenases. These enzymes, referred to as Cox-1 and Cox-2, are a necessary part of the production of prostaglandins. Prostaglandins, in turn, are messenger substances that promote inflammation and support the transmission of pain signals to the brain.

Celecoxib should not be taken with a high-fat meal. Fatty foods can delay absorption of the drug by up to an hour.

 

Pharmacokinetics

Absorption

Celecoxib is well absorbed, reaching peak plasma concentrations after approximately 2 to 3 hours. Administration with meals (high-fat food) delays the absorption of celecoxib by approximately 1 hour and increases its bioavailability by approximately 20%.

Distribution

Plasma protein binding is approximately 97%.

Biotransformation

Celecoxib is mainly catalyzed by  CYP2C9  to three inactive metabolites.

Elimination

Less than 1% of the administered dose is excreted unchanged in the urine. The elimination half-life is 8 to 12 hours, steady state is reached after 5 days of treatment.

 

Dosage of Celebrex (Celecoxib)

The shortest possible duration of treatment and the lowest effective daily dose should be used since the cardiovascular risk of celecoxib may increase with dose and duration of exposure. For all indications, the maximum recommended daily dose is 400 mg, but if efficacy does not improve within 2 weeks after increasing the dose, other therapies should be considered.

Adult

Irritable states of degenerative joint diseases (activated arthrosis)

The recommended daily dose is 200 mg once a day or 100 mg twice a day. The dose may be increased to 200 mg twice a day if necessary.

Rheumatoid arthritis

The recommended starting dose is 100 mg twice a day. The dose can be increased to 200 mg twice a day if needed.

Ankylosing spondylitis

The recommended daily dose is 200 mg once a day or 100 mg twice a day. The dose may be increased to 200 mg twice a day or 400 mg once a day if necessary.

Elderly patients

The starting dose is also 200 mg and can be increased to 200 mg twice a day if needed. Particular caution should be exercised in elderly patients weighing less than 50 kg.

Children and youth

Celecoxib is not indicated for use in children.

Liver dysfunction

In patients with moderate hepatic impairment, treatment should be started at half the recommended dose, but experience in such patients is limited.

Renal dysfunction

As experience is limited, patients with mild or moderate renal impairment should be treated with caution.

side effects

The most common side effects of celecoxib include gastrointestinal discomfort, respiratory infections, dizziness, insomnia, headache, edema, and increases in blood pressure.

Additional information

Dosage

100 mg, 200 mg

Quantity

30, 60, 90, 120, 180

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