$ 194.02$ 1,477.02

Category: Women’s Health
Commercial name: Dostinex
Active ingredient: Cabergoline
Production form: Pills
Available dosage: 0.3 mg, 0.5 mg

SKU: N/A Category: Tags: ,


Dostinex. Dosage, Side Effects, Interactions

Dostinex (cabergoline) is a dopamine receptor antagonist used to treat a hormone imbalance where there is too much prolactin in the blood (also called hyperprolactinemia).

What are side effects of Dostinex?

Common side effects of Dostinex include:

  • Nausea,
  • Vomit,
  • Stomach upset or pain,
  • Indigestion,
  • Constipation,
  • Gases,
  • Dizziness,
  • Spinning feeling,
  • Drowsiness,
  • Sleepiness,
  • Nervousness,
  • Fatigue,
  • Headache,
  • Depressed mood,
  • Hot flashes,
  • Numbness or tingling sensation, or
  • Dry mouth.

Tell your doctor if you experience any rare but serious side effects of Dostinex, including:

  • Shortness of breath,
  • Persistent cough,
  • Swelling ankles or feet,
  • Unusual tiredness,
  • Mental/mood changes (like nervousness),
  • Unusually strong urges (such as increased gambling, increased sexual urges),
  • Blurred vision,
  • Painful menstruation or
  • Chest pain.


DOSTINEX tablets contain cabergoline, a dopamine receptor agonist. The chemical name for cabergoline is 1-[(6-allylergolin-8β-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea. Its empirical formula is C 26 H 37 N 5 OR two and its molecular weight is 451.62. The structural formula is as follows:


Cabergoline is a white powder soluble in ethyl alcohol, chloroform and N,N-dimethylformamide (DMF). sparingly soluble in 0.1 N hydrochloric acid; very poorly soluble in n-hexane; and insoluble in water.

DOSTINEX tablets for oral administration contain 0.5 mg of cabergoline. Inactive ingredients consist of Leucine (USP) and Lactose (NF).

Indications & Dosage of Dostinex


DOSTINEX tablets are indicated for the treatment of hyperprolactinemic disorders, either idiopathic or due to pituitary adenomas.


The recommended dosage of DOSTINEX tablets at the beginning of therapy is 0.25 mg twice a week. The dose may be increased by 0.25 mg twice weekly up to a dose of 1 mg twice weekly according to the patient’s serum prolactin level. Before starting treatment, a cardiovascular evaluation should be performed and echocardiography should be considered to assess valvular disease.

Dose increases should not be made faster than every 4 weeks to allow the doctor to assess the patient’s response to each dose level. If the patient does not respond adequately and no additional benefit is observed at higher doses, the lowest dose that has achieved the maximum response should be used and other therapeutic approaches should be considered. Patients receiving long-term treatment with DOSTINEX should have regular cardiac evaluation and consider echocardiography.

After normal serum prolactin levels have been maintained for 6 months, DOSTINEX may be discontinued, with periodic monitoring of serum prolactin levels to determine if and when DOSTINEX treatment should be restarted. Durability of efficacy beyond 24 months of DOSTINEX therapy has not been demonstrated.


DOSTINEX tablets are white, ridged, capsule-shaped tablets containing 0.5 mg of cabergoline. Each tablet is scored on one side and has the letter P and the letter U on either side of the score line. The number 700 is engraved on the other side of the tablet.


Body as a whole: facial oedema, flu-like symptoms, malaise

Cardiovascular system: hypotension, syncope, palpitations

Digestive tract: dry mouth, gas, diarrhea, anorexia

Metabolism and nutritional system: weight loss, weight gain

Nervous system: drowsiness, nervousness, paresthesia, insomnia, anxiety

Respiratory system: nasal congestion, nosebleeds

Skin and limbs: acne, itching

Special senses: abnormal vision

Urogenital system: dysmenorrhea, increased libido

The safety of cabergoline has been evaluated in approximately 1,200 patients with Parkinson’s disease in controlled and uncontrolled studies at doses up to 11.5 mg/day, which significantly exceeds the maximum recommended dose of cabergoline in hyperprolactinaemic disorders. In addition to the adverse events seen in patients with hyperprolactinaemic disorders, the most common adverse events in patients with Parkinson’s disease were dyskinesia, hallucinations, confusion and peripheral edema. Heart failure, pleural effusion, pulmonary fibrosis, and gastric or duodenal ulcers have occurred rarely. One case of constrictive pericarditis was reported.

Post-market surveillance data

The following events have been reported in association with DOSTINEX: Valvular heart disease and extracardiac fibrotic reactions

Other events have been reported in association with cabergoline: hypersexuality, increased libido, and pathological gambling. In addition, cases of alopecia, aggression and psychotic disorders have been reported in patients taking DOSTINEX. Some of these reports have involved patients who have previously had adverse reactions to dopamine agonist products.


DOSTINEX should not be administered concomitantly with D-antagonists such as phenothiazines, butyrophenones, thioxanthenes or metoclopramide.




Dopamine agonists should generally not be used in patients with pregnancy-related hypertension, e.g. B. Preeclampsia, eclampsia and postpartum hypertension, unless the potential benefit outweighs the potential risk.

Fibrotic Complications

Valvular disease

All patients should have a cardiovascular evaluation, including an echocardiogram, to assess the possible presence of valvular disease. If valvular disease is identified, the patient should not be treated with DOSTINEX. Post-marketing cases of valvular heart disease have been reported in patients receiving DOSTINEX. These cases generally occurred during the administration of high doses of DOSTINEX (> 2 mg/day) for the treatment of Parkinson’s disease. Cases of valvular heart disease have also been reported in patients receiving lower doses of DOSTINEX for the treatment of hyperprolactinaemic disorders

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Additional information


0.3 mg, 0.5 mg


30, 60, 90, 120, 180


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